Gentamicin Induced Nephrotoxicity in Long Evans Rat - An Experimental Study

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Gentamicin Induced Nephrotoxicity in Long Evans Rat - An Experimental Study

Context: Gentamicin is an antibiotic used in gram-negative infection. It is an nephrotoxic agent. Proximal tubular epithelial cells are selectively sensitive to gentamicin. Objective: To observe the toxic effect of gentamicin on epithelial cells of proximal convoluted tubule in Long Evans rats. Study design: An experimental study. Plan and period of study: The study was carried out in the Depar...

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Gentamicin is an important aminoglycoside antibiotic. However its use is limited to serious and life threatening gram negative infections, because of its high nephrotoxicity potential in patients. There are reports that safranal, the active ingredient of saffron with antioxidant properties, exerts protective effect against ischemic injuries occurred by certain nephrotoxins including gentamicin....

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Does Propylthiouracil Increase the Gentamicin-Induced Nephrotoxicity In Rat?

  Objective(s): The aim of this study was to evaluate the effect of subacute administration of propylthiouracil (PTU) on gentamicin (GM)-induced nephrotoxicity in male rats.   Materials and Methods: Male Wistar rats were divided into 4 experimental groups as follow: (1) Control group: isotonic saline (1 ml/kg, IP. for 18 d), (2) GM group: 100 mg/kg, IP for 8 d, (3) PTU group: PTU...

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Long-term protection of polyaspartic acid in experimental gentamicin nephrotoxicity.

Polyaspartic Acid (PAA) protects the kidney from experimental gentamicin nephrotoxicity despite large increases in renal cortical gentamicin content. In these experiments, prominent cytoplasmic vacuoles were noted in all animals that received PAA with or without gentamicin. The present study showed that there were no renal structural or functional consequences of PAA given alone or with gentami...

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protective effect of safranal against gentamicin-induced nephrotoxicity in rat

gentamicin is an important aminoglycoside antibiotic. however its use is limited to serious and life threatening gram negative infections, because of its high nephrotoxicity potential in patients. there are reports that safranal, the active ingredient of saffron with antioxidant properties, exerts protective effect against ischemic injuries occurred by certain nephrotoxins including gentamicin....

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ژورنال

عنوان ژورنال: Bangladesh Journal of Anatomy

سال: 1970

ISSN: 2219-3049,1817-065X

DOI: 10.3329/bja.v7i2.6088